Serveur d'exploration sur les relations entre la France et l'Australie

Attention, ce site est en cours de développement !
Attention, site généré par des moyens informatiques à partir de corpus bruts.
Les informations ne sont donc pas validées.

Human cytochromes P450

Identifieur interne : 00C441 ( Main/Exploration ); précédent : 00C440; suivant : 00C442

Human cytochromes P450

Auteurs : Julia A. Hasler [Zimbabwe] ; Ronald Estabrook [États-Unis] ; Michael Murray [Australie] ; Irina Pikuleva [États-Unis] ; Michael Waterman [États-Unis] ; Jorge Capdevila [États-Unis] ; Vijakumar Holla [États-Unis] ; Christian Helvig [États-Unis] ; John R. Falck [États-Unis] ; Geoffrey Farrell [Australie] ; Laurence S. Kaminsky [États-Unis] ; Simon D. Spivack [États-Unis] ; Eric Boitier [France] ; Philippe Beaune [France]

Source :

RBID : ISTEX:AD6BE9C9C95C8D971CB1DA6AF0A78F5EB217FFA9

Descripteurs français

English descriptors

Abstract

Abstract: The cytochrome P450 proteins (CYPs) are a family of haem proteins resulting from expression of a gene super-family that currently contains around 1000 members in species ranging from bacteria through to plants and animals. In humans, about 40 different CYPs are present and these play critical roles by catalyzing reactions in: (a) the metabolism of drugs, environmental pollutants and other xenobiotics; (b) the biosynthesis of steroid hormones; (c) the oxidation of unsaturated fatty acids to intracellular messengers; and (d) the stereo- and regio-specific metabolism of fat-soluble vitamins. This review deals with aspects of cytochrome P450s of relevance to human physiology, biochemistry, pharmacology and medicine. Topics reviewed include: pharmacogenetics of CYPs, induction and inhibition of these haem proteins, their role in metabolism of endogenous compounds such as steroids and eicosanoids, the effect of disease on CYP function, CYPs and cancer, and CYPs as targets of antibodies in immune-mediated diseases.

Url:
DOI: 10.1016/S0098-2997(99)00005-9


Affiliations:


Links toward previous steps (curation, corpus...)


Le document en format XML

<record>
<TEI wicri:istexFullTextTei="biblStruct">
<teiHeader>
<fileDesc>
<titleStmt>
<title>Human cytochromes P450</title>
<author>
<name sortKey="Hasler, Julia A" sort="Hasler, Julia A" uniqKey="Hasler J" first="Julia A" last="Hasler">Julia A. Hasler</name>
</author>
<author>
<name sortKey="Estabrook, Ronald" sort="Estabrook, Ronald" uniqKey="Estabrook R" first="Ronald" last="Estabrook">Ronald Estabrook</name>
</author>
<author>
<name sortKey="Murray, Michael" sort="Murray, Michael" uniqKey="Murray M" first="Michael" last="Murray">Michael Murray</name>
</author>
<author>
<name sortKey="Pikuleva, Irina" sort="Pikuleva, Irina" uniqKey="Pikuleva I" first="Irina" last="Pikuleva">Irina Pikuleva</name>
</author>
<author>
<name sortKey="Waterman, Michael" sort="Waterman, Michael" uniqKey="Waterman M" first="Michael" last="Waterman">Michael Waterman</name>
</author>
<author>
<name sortKey="Capdevila, Jorge" sort="Capdevila, Jorge" uniqKey="Capdevila J" first="Jorge" last="Capdevila">Jorge Capdevila</name>
</author>
<author>
<name sortKey="Holla, Vijakumar" sort="Holla, Vijakumar" uniqKey="Holla V" first="Vijakumar" last="Holla">Vijakumar Holla</name>
</author>
<author>
<name sortKey="Helvig, Christian" sort="Helvig, Christian" uniqKey="Helvig C" first="Christian" last="Helvig">Christian Helvig</name>
</author>
<author>
<name sortKey="Falck, John R" sort="Falck, John R" uniqKey="Falck J" first="John R" last="Falck">John R. Falck</name>
</author>
<author>
<name sortKey="Farrell, Geoffrey" sort="Farrell, Geoffrey" uniqKey="Farrell G" first="Geoffrey" last="Farrell">Geoffrey Farrell</name>
</author>
<author>
<name sortKey="Kaminsky, Laurence S" sort="Kaminsky, Laurence S" uniqKey="Kaminsky L" first="Laurence S" last="Kaminsky">Laurence S. Kaminsky</name>
</author>
<author>
<name sortKey="Spivack, Simon D" sort="Spivack, Simon D" uniqKey="Spivack S" first="Simon D" last="Spivack">Simon D. Spivack</name>
</author>
<author>
<name sortKey="Boitier, Eric" sort="Boitier, Eric" uniqKey="Boitier E" first="Eric" last="Boitier">Eric Boitier</name>
</author>
<author>
<name sortKey="Beaune, Philippe" sort="Beaune, Philippe" uniqKey="Beaune P" first="Philippe" last="Beaune">Philippe Beaune</name>
</author>
</titleStmt>
<publicationStmt>
<idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:AD6BE9C9C95C8D971CB1DA6AF0A78F5EB217FFA9</idno>
<date when="1999" year="1999">1999</date>
<idno type="doi">10.1016/S0098-2997(99)00005-9</idno>
<idno type="url">https://api.istex.fr/document/AD6BE9C9C95C8D971CB1DA6AF0A78F5EB217FFA9/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">002100</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">002100</idno>
<idno type="wicri:Area/Istex/Curation">002100</idno>
<idno type="wicri:Area/Istex/Checkpoint">002103</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">002103</idno>
<idno type="wicri:doubleKey">0098-2997:1999:Hasler J:human:cytochromes:p</idno>
<idno type="wicri:Area/Main/Merge">00D414</idno>
<idno type="wicri:Area/Main/Curation">00C441</idno>
<idno type="wicri:Area/Main/Exploration">00C441</idno>
</publicationStmt>
<sourceDesc>
<biblStruct>
<analytic>
<title level="a">Human cytochromes P450</title>
<author>
<name sortKey="Hasler, Julia A" sort="Hasler, Julia A" uniqKey="Hasler J" first="Julia A" last="Hasler">Julia A. Hasler</name>
<affiliation wicri:level="1">
<country wicri:rule="url">Zimbabwe</country>
</affiliation>
<affiliation wicri:level="1">
<country xml:lang="fr">Zimbabwe</country>
<wicri:regionArea>Department of Biochemistry, University of Zimbabwe, 167 Mt. Pleasant, Harare</wicri:regionArea>
<wicri:noRegion>Harare</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Estabrook, Ronald" sort="Estabrook, Ronald" uniqKey="Estabrook R" first="Ronald" last="Estabrook">Ronald Estabrook</name>
<affiliation wicri:level="2">
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biochemistry, University of Texas, South Western Medical Centre, 5323 Harry Hines Blvd, Dallas, TX 75235</wicri:regionArea>
<placeName>
<region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Murray, Michael" sort="Murray, Michael" uniqKey="Murray M" first="Michael" last="Murray">Michael Murray</name>
<affiliation wicri:level="1">
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of Physiology and Pharmacology, University of New South Wales, Sydney, NSW 2052</wicri:regionArea>
<wicri:noRegion>NSW 2052</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Pikuleva, Irina" sort="Pikuleva, Irina" uniqKey="Pikuleva I" first="Irina" last="Pikuleva">Irina Pikuleva</name>
<affiliation wicri:level="2">
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232-0146</wicri:regionArea>
<placeName>
<region type="state">Tennessee</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Waterman, Michael" sort="Waterman, Michael" uniqKey="Waterman M" first="Michael" last="Waterman">Michael Waterman</name>
<affiliation wicri:level="2">
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232-0146</wicri:regionArea>
<placeName>
<region type="state">Tennessee</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Capdevila, Jorge" sort="Capdevila, Jorge" uniqKey="Capdevila J" first="Jorge" last="Capdevila">Jorge Capdevila</name>
<affiliation wicri:level="1">
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Departments of Medicine and Biochemistry, Vanderbilt University Medical School, Nashville</wicri:regionArea>
<wicri:noRegion>Nashville</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Holla, Vijakumar" sort="Holla, Vijakumar" uniqKey="Holla V" first="Vijakumar" last="Holla">Vijakumar Holla</name>
<affiliation wicri:level="1">
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Departments of Medicine and Biochemistry, Vanderbilt University Medical School, Nashville</wicri:regionArea>
<wicri:noRegion>Nashville</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Helvig, Christian" sort="Helvig, Christian" uniqKey="Helvig C" first="Christian" last="Helvig">Christian Helvig</name>
<affiliation wicri:level="1">
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Departments of Medicine and Biochemistry, Vanderbilt University Medical School, Nashville</wicri:regionArea>
<wicri:noRegion>Nashville</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Falck, John R" sort="Falck, John R" uniqKey="Falck J" first="John R" last="Falck">John R. Falck</name>
<affiliation wicri:level="2">
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biochemistry, University of Texas, South Western Medical Centre, 5323 Harry Hines Blvd, Dallas, TX 75235</wicri:regionArea>
<placeName>
<region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Farrell, Geoffrey" sort="Farrell, Geoffrey" uniqKey="Farrell G" first="Geoffrey" last="Farrell">Geoffrey Farrell</name>
<affiliation wicri:level="1">
<country xml:lang="fr">Australie</country>
<wicri:regionArea>University of Sydney at Westmead Hospital, Westmead Hospital, Westmead, NSW 2145</wicri:regionArea>
<wicri:noRegion>NSW 2145</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Kaminsky, Laurence S" sort="Kaminsky, Laurence S" uniqKey="Kaminsky L" first="Laurence S" last="Kaminsky">Laurence S. Kaminsky</name>
<affiliation wicri:level="2">
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>NY State Department of Health, Wadsworth Center, P.O. Box 509, Albany, NY 12201-0509</wicri:regionArea>
<placeName>
<region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Spivack, Simon D" sort="Spivack, Simon D" uniqKey="Spivack S" first="Simon D" last="Spivack">Simon D. Spivack</name>
<affiliation wicri:level="2">
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>NY State Department of Health, Wadsworth Center, P.O. Box 509, Albany, NY 12201-0509</wicri:regionArea>
<placeName>
<region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Boitier, Eric" sort="Boitier, Eric" uniqKey="Boitier E" first="Eric" last="Boitier">Eric Boitier</name>
<affiliation wicri:level="1">
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM U 490, Toxicologie Moléculaire, Université René Descartes, 45 rue des Saints-Pères, F-75270 Paris, Cedex 06</wicri:regionArea>
<wicri:noRegion>Cedex 06</wicri:noRegion>
<wicri:noRegion>Cedex 06</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Beaune, Philippe" sort="Beaune, Philippe" uniqKey="Beaune P" first="Philippe" last="Beaune">Philippe Beaune</name>
<affiliation wicri:level="1">
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM U 490, Toxicologie Moléculaire, Université René Descartes, 45 rue des Saints-Pères, F-75270 Paris, Cedex 06</wicri:regionArea>
<wicri:noRegion>Cedex 06</wicri:noRegion>
<wicri:noRegion>Cedex 06</wicri:noRegion>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series>
<title level="j">Molecular Aspects of Medicine</title>
<title level="j" type="abbrev">JMAM</title>
<idno type="ISSN">0098-2997</idno>
<imprint>
<publisher>ELSEVIER</publisher>
<date type="published" when="1999">1999</date>
<biblScope unit="volume">20</biblScope>
<biblScope unit="issue">1–2</biblScope>
<biblScope unit="page" from="1">1</biblScope>
<biblScope unit="page" to="137">137</biblScope>
</imprint>
<idno type="ISSN">0098-2997</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt>
<idno type="ISSN">0098-2997</idno>
</seriesStmt>
</fileDesc>
<profileDesc>
<textClass>
<keywords scheme="KwdEn" xml:lang="en">
<term>Acad</term>
<term>Acid</term>
<term>Acta</term>
<term>Adduct</term>
<term>Adrenal</term>
<term>Adrenal cortex</term>
<term>Adrenodoxin</term>
<term>African populations</term>
<term>Ahonen</term>
<term>Aih2</term>
<term>Aklillu</term>
<term>Alcoholic liver disease</term>
<term>Aldosterone</term>
<term>Allele</term>
<term>Allele frequency</term>
<term>Allelic</term>
<term>Amine</term>
<term>Amino</term>
<term>Amino acids</term>
<term>Androgen</term>
<term>Animal model</term>
<term>Anticancer</term>
<term>Anticancer drugs</term>
<term>Anticonvulsant</term>
<term>Antidepressant</term>
<term>Antipyrine</term>
<term>Antipyrine metabolism</term>
<term>Aoyama</term>
<term>Aps1</term>
<term>Arachidonate</term>
<term>Arachidonic</term>
<term>Arachidonic acid</term>
<term>Autoantibody</term>
<term>Autoantigen</term>
<term>Autoimmune</term>
<term>Autoimmune disease</term>
<term>Autoimmune hepatitis</term>
<term>Autoimmune hepatitis type</term>
<term>Autoimmune polyglandular syndrome type</term>
<term>Autoimmunity</term>
<term>Autoreactive</term>
<term>Beaune</term>
<term>Benhamou</term>
<term>Bertilsson</term>
<term>Bile acids</term>
<term>Bioactivated</term>
<term>Bioactivation</term>
<term>Biochem</term>
<term>Biochemistry</term>
<term>Biochim</term>
<term>Biol</term>
<term>Biom</term>
<term>Biophys</term>
<term>Biosynthesis</term>
<term>Biosynthetic</term>
<term>Biotransformation</term>
<term>Bourdi</term>
<term>Broly</term>
<term>Brosis</term>
<term>Buschenfelde</term>
<term>Cancer epid</term>
<term>Cantrill</term>
<term>Capdevila</term>
<term>Caporaso</term>
<term>Carbamazepine</term>
<term>Carcinogen</term>
<term>Carcinogenesis</term>
<term>Carcinogenic</term>
<term>Carcinoma</term>
<term>Catalysis</term>
<term>Catalyze</term>
<term>Catalyzes</term>
<term>Catalyzing</term>
<term>Caucasian</term>
<term>Cdna</term>
<term>Chacos</term>
<term>Characterised</term>
<term>Chem</term>
<term>Cholestasis</term>
<term>Chromosome</term>
<term>Chronic hepatitis</term>
<term>Cirrhosis</term>
<term>Cirrhotic</term>
<term>Clin</term>
<term>Codon</term>
<term>Commun</term>
<term>Constitutive</term>
<term>Coon</term>
<term>Corticosterone</term>
<term>Cortisol</term>
<term>Coumarin</term>
<term>Covalent</term>
<term>Covalent binding</term>
<term>Covalently</term>
<term>Coverdale</term>
<term>Cyclophosphamide</term>
<term>Cyp1a</term>
<term>Cyp3a</term>
<term>Cyps</term>
<term>Cytochrome</term>
<term>Cytokine</term>
<term>Cytotoxic</term>
<term>Cytotoxicity</term>
<term>Dahl</term>
<term>Daly</term>
<term>Dansette</term>
<term>Debrisoquine</term>
<term>Deletion</term>
<term>Diazepam</term>
<term>Dihydralazine</term>
<term>Drug metab</term>
<term>Drug metabolism</term>
<term>Drug oxidations</term>
<term>Eets</term>
<term>Eichelbaum</term>
<term>Eicosanoid</term>
<term>Eicosanoids</term>
<term>Eliasson</term>
<term>Enantioselective</term>
<term>Encoding</term>
<term>Endocrinol</term>
<term>Endocrinology</term>
<term>Endogenous</term>
<term>Endoplasmic</term>
<term>Endoplasmic reticulum</term>
<term>Endotoxin</term>
<term>Enzyme</term>
<term>Enzyme activity</term>
<term>Epid</term>
<term>Epitope</term>
<term>Epoxidation</term>
<term>Epoxide</term>
<term>Epoxyeicosatrienoic</term>
<term>Epoxyeicosatrienoic acids</term>
<term>Epoxygenase</term>
<term>Erythromycin</term>
<term>Estabrook</term>
<term>Estradiol</term>
<term>Estrogen</term>
<term>Ethiopian</term>
<term>Exon</term>
<term>Extrahepatic</term>
<term>Falck</term>
<term>Fatty acid</term>
<term>Fatty acids</term>
<term>Ferric</term>
<term>Gaedigk</term>
<term>Gastroenterology</term>
<term>Gelboin</term>
<term>Gene</term>
<term>Gene expression</term>
<term>Genetic polymorphism</term>
<term>Genetic polymorphisms</term>
<term>Genotype</term>
<term>Genotyping</term>
<term>Glomerulosa</term>
<term>Glucocorticoid</term>
<term>Goldstein</term>
<term>Gonzalez</term>
<term>Growth hormone</term>
<term>Guengerich</term>
<term>Gustafsson</term>
<term>Guzelian</term>
<term>Halothane</term>
<term>Hasler</term>
<term>Hayashi</term>
<term>Heme</term>
<term>Hemeproteins</term>
<term>Hepatic</term>
<term>Hepatic cyps</term>
<term>Hepatic cytochrome</term>
<term>Hepatitis</term>
<term>Hepatocellular</term>
<term>Hepatocyte</term>
<term>Hepatocytes</term>
<term>Hepatol</term>
<term>Hepatology</term>
<term>Heterocyclic</term>
<term>Hirvonen</term>
<term>Homberg</term>
<term>Huang</term>
<term>Human cytochrome</term>
<term>Human hepatocytes</term>
<term>Human liver</term>
<term>Human liver microsomes</term>
<term>Human lung</term>
<term>Hydrolase</term>
<term>Hydroxylase</term>
<term>Hydroxylation</term>
<term>Hypertension</term>
<term>Hypertensive</term>
<term>Ifosfamide</term>
<term>Imaoka</term>
<term>Immune</term>
<term>Immune response</term>
<term>Immunol</term>
<term>Inducer</term>
<term>Inducibility</term>
<term>Inducible</term>
<term>Inhibitor</term>
<term>Interethnic</term>
<term>Interferon</term>
<term>Interindividual</term>
<term>Iodothyronine</term>
<term>Isoform</term>
<term>Isoforms</term>
<term>Jacobson</term>
<term>Jiang</term>
<term>Johansson</term>
<term>Kadlubar</term>
<term>Kagawa</term>
<term>Karara</term>
<term>Kawajiri</term>
<term>Keeney</term>
<term>Kenna</term>
<term>Kimura</term>
<term>Krohn</term>
<term>Kunze</term>
<term>Kupfer</term>
<term>Kusunose</term>
<term>Laethem</term>
<term>Lancet</term>
<term>Lauric</term>
<term>Leeder</term>
<term>Lett</term>
<term>Leukocyte</term>
<term>Leydig</term>
<term>Liddle</term>
<term>Lipid</term>
<term>Liver</term>
<term>Liver disease</term>
<term>Liver microsomes</term>
<term>Loeper</term>
<term>Lung cancer</term>
<term>Lymphocyte</term>
<term>Macrolide</term>
<term>Makita</term>
<term>Male rats</term>
<term>Mansuy</term>
<term>Masimirembwa</term>
<term>Mcgi</term>
<term>Mclean</term>
<term>Mediator</term>
<term>Mephenytoin</term>
<term>Metab</term>
<term>Metabolic</term>
<term>Metabolic ratios</term>
<term>Metaboliser</term>
<term>Metabolisers</term>
<term>Metabolism</term>
<term>Metabolite</term>
<term>Metabolizers</term>
<term>Metabolizing</term>
<term>Microsomal</term>
<term>Microsome</term>
<term>Mimicry</term>
<term>Mitochondrial</term>
<term>Mitochondrion</term>
<term>Molecular aspects</term>
<term>Molecular mimicry</term>
<term>Molecular oxygen</term>
<term>Monooxygenase</term>
<term>Montellano</term>
<term>Morais</term>
<term>Mrna</term>
<term>Mrna levels</term>
<term>Mspi</term>
<term>Mutant</term>
<term>Mutation</term>
<term>Nadph</term>
<term>Natl</term>
<term>Nebert</term>
<term>Neoantigen</term>
<term>Neufeld</term>
<term>Nonsteroidogenic</term>
<term>Oates</term>
<term>Okuda</term>
<term>Oliw</term>
<term>Omeprazole</term>
<term>Omura</term>
<term>Oriental populations</term>
<term>Orphenadrine</term>
<term>Ortiz</term>
<term>Other hand</term>
<term>Ovarian</term>
<term>Oxidase</term>
<term>Oxidative</term>
<term>Oxidative metabolism</term>
<term>Oxidized</term>
<term>Oxygenase</term>
<term>Pahs</term>
<term>Pathophysiological</term>
<term>Pathophysiology</term>
<term>Pathway</term>
<term>Peptide</term>
<term>Persson</term>
<term>Pessayre</term>
<term>Pharm</term>
<term>Pharmacogenetics</term>
<term>Pharmacokinetic</term>
<term>Pharmacol</term>
<term>Phenobarbital</term>
<term>Phenotype</term>
<term>Phenotypic</term>
<term>Phenotyping</term>
<term>Phenytoin</term>
<term>Physiol</term>
<term>Plasma membrane</term>
<term>Platelet</term>
<term>Polycyclic</term>
<term>Polyglandular</term>
<term>Polymorphic</term>
<term>Polymorphism</term>
<term>Polymorphonuclear</term>
<term>Poor metabolisers</term>
<term>Pregnenolone</term>
<term>Prev</term>
<term>Proc</term>
<term>Procarcinogens</term>
<term>Progesterone</term>
<term>Proguanil</term>
<term>Propranolol</term>
<term>Prostaglandin</term>
<term>Prostanoids</term>
<term>Prosthetic</term>
<term>Protein levels</term>
<term>Rahman</term>
<term>Reactive</term>
<term>Reactive metabolite</term>
<term>Reactive metabolites</term>
<term>Receptor</term>
<term>Recognise</term>
<term>Recombinant</term>
<term>Reductase</term>
<term>Renal</term>
<term>Reticulum</term>
<term>Rifampicin</term>
<term>Riley</term>
<term>Schuetz</term>
<term>Schwartzman</term>
<term>Severe liver disease</term>
<term>Sharma</term>
<term>Shimada</term>
<term>Shunting</term>
<term>Sparteine</term>
<term>Steroid</term>
<term>Steroid hormones</term>
<term>Steroidogenesis</term>
<term>Steroidogenic</term>
<term>Sterol</term>
<term>Subfamily</term>
<term>Sugimura</term>
<term>Susceptibility</term>
<term>Synthase</term>
<term>Tamoxifen</term>
<term>Tanzanian</term>
<term>Tapner</term>
<term>Testis</term>
<term>Testosterone</term>
<term>Theophylline</term>
<term>Therapeut</term>
<term>Thromboxane</term>
<term>Thummel</term>
<term>Tienilic</term>
<term>Tienilic acid</term>
<term>Tinel</term>
<term>Tolbutamide</term>
<term>Toxicity</term>
<term>Toxicol</term>
<term>Transcriptional</term>
<term>Transferase</term>
<term>Ultrarapid</term>
<term>Ultrarapid metabolisers</term>
<term>Variant</term>
<term>Vergani</term>
<term>Wang</term>
<term>Watanabe</term>
<term>Waterman</term>
<term>Watkins</term>
<term>Waxman</term>
<term>Wrighton</term>
<term>Xenobiotic</term>
<term>Xenobiotica</term>
<term>Xenobiotics</term>
<term>Yamamoto</term>
<term>Yokotani</term>
<term>Zaluzny</term>
<term>Zeldin</term>
<term>Zhang</term>
<term>Zimbabwean</term>
</keywords>
<keywords scheme="Teeft" xml:lang="en">
<term>Acad</term>
<term>Acid</term>
<term>Acta</term>
<term>Adduct</term>
<term>Adrenal</term>
<term>Adrenal cortex</term>
<term>Adrenodoxin</term>
<term>African populations</term>
<term>Ahonen</term>
<term>Aih2</term>
<term>Aklillu</term>
<term>Alcoholic liver disease</term>
<term>Aldosterone</term>
<term>Allele</term>
<term>Allele frequency</term>
<term>Allelic</term>
<term>Amine</term>
<term>Amino</term>
<term>Amino acids</term>
<term>Androgen</term>
<term>Animal model</term>
<term>Anticancer</term>
<term>Anticancer drugs</term>
<term>Anticonvulsant</term>
<term>Antidepressant</term>
<term>Antipyrine</term>
<term>Antipyrine metabolism</term>
<term>Aoyama</term>
<term>Aps1</term>
<term>Arachidonate</term>
<term>Arachidonic</term>
<term>Arachidonic acid</term>
<term>Autoantibody</term>
<term>Autoantigen</term>
<term>Autoimmune</term>
<term>Autoimmune disease</term>
<term>Autoimmune hepatitis</term>
<term>Autoimmune hepatitis type</term>
<term>Autoimmune polyglandular syndrome type</term>
<term>Autoimmunity</term>
<term>Autoreactive</term>
<term>Beaune</term>
<term>Benhamou</term>
<term>Bertilsson</term>
<term>Bile acids</term>
<term>Bioactivated</term>
<term>Bioactivation</term>
<term>Biochem</term>
<term>Biochemistry</term>
<term>Biochim</term>
<term>Biol</term>
<term>Biom</term>
<term>Biophys</term>
<term>Biosynthesis</term>
<term>Biosynthetic</term>
<term>Biotransformation</term>
<term>Bourdi</term>
<term>Broly</term>
<term>Brosis</term>
<term>Buschenfelde</term>
<term>Cancer epid</term>
<term>Cantrill</term>
<term>Capdevila</term>
<term>Caporaso</term>
<term>Carbamazepine</term>
<term>Carcinogen</term>
<term>Carcinogenesis</term>
<term>Carcinogenic</term>
<term>Carcinoma</term>
<term>Catalysis</term>
<term>Catalyze</term>
<term>Catalyzes</term>
<term>Catalyzing</term>
<term>Caucasian</term>
<term>Cdna</term>
<term>Chacos</term>
<term>Characterised</term>
<term>Chem</term>
<term>Cholestasis</term>
<term>Chromosome</term>
<term>Chronic hepatitis</term>
<term>Cirrhosis</term>
<term>Cirrhotic</term>
<term>Clin</term>
<term>Codon</term>
<term>Commun</term>
<term>Constitutive</term>
<term>Coon</term>
<term>Corticosterone</term>
<term>Cortisol</term>
<term>Coumarin</term>
<term>Covalent</term>
<term>Covalent binding</term>
<term>Covalently</term>
<term>Coverdale</term>
<term>Cyclophosphamide</term>
<term>Cyp1a</term>
<term>Cyp3a</term>
<term>Cyps</term>
<term>Cytochrome</term>
<term>Cytokine</term>
<term>Cytotoxic</term>
<term>Cytotoxicity</term>
<term>Dahl</term>
<term>Daly</term>
<term>Dansette</term>
<term>Debrisoquine</term>
<term>Deletion</term>
<term>Diazepam</term>
<term>Dihydralazine</term>
<term>Drug metab</term>
<term>Drug metabolism</term>
<term>Drug oxidations</term>
<term>Eets</term>
<term>Eichelbaum</term>
<term>Eicosanoid</term>
<term>Eicosanoids</term>
<term>Eliasson</term>
<term>Enantioselective</term>
<term>Encoding</term>
<term>Endocrinol</term>
<term>Endocrinology</term>
<term>Endogenous</term>
<term>Endoplasmic</term>
<term>Endoplasmic reticulum</term>
<term>Endotoxin</term>
<term>Enzyme</term>
<term>Enzyme activity</term>
<term>Epid</term>
<term>Epitope</term>
<term>Epoxidation</term>
<term>Epoxide</term>
<term>Epoxyeicosatrienoic</term>
<term>Epoxyeicosatrienoic acids</term>
<term>Epoxygenase</term>
<term>Erythromycin</term>
<term>Estabrook</term>
<term>Estradiol</term>
<term>Estrogen</term>
<term>Ethiopian</term>
<term>Exon</term>
<term>Extrahepatic</term>
<term>Falck</term>
<term>Fatty acid</term>
<term>Fatty acids</term>
<term>Ferric</term>
<term>Gaedigk</term>
<term>Gastroenterology</term>
<term>Gelboin</term>
<term>Gene</term>
<term>Gene expression</term>
<term>Genetic polymorphism</term>
<term>Genetic polymorphisms</term>
<term>Genotype</term>
<term>Genotyping</term>
<term>Glomerulosa</term>
<term>Glucocorticoid</term>
<term>Goldstein</term>
<term>Gonzalez</term>
<term>Growth hormone</term>
<term>Guengerich</term>
<term>Gustafsson</term>
<term>Guzelian</term>
<term>Halothane</term>
<term>Hasler</term>
<term>Hayashi</term>
<term>Heme</term>
<term>Hemeproteins</term>
<term>Hepatic</term>
<term>Hepatic cyps</term>
<term>Hepatic cytochrome</term>
<term>Hepatitis</term>
<term>Hepatocellular</term>
<term>Hepatocyte</term>
<term>Hepatocytes</term>
<term>Hepatol</term>
<term>Hepatology</term>
<term>Heterocyclic</term>
<term>Hirvonen</term>
<term>Homberg</term>
<term>Huang</term>
<term>Human cytochrome</term>
<term>Human hepatocytes</term>
<term>Human liver</term>
<term>Human liver microsomes</term>
<term>Human lung</term>
<term>Hydrolase</term>
<term>Hydroxylase</term>
<term>Hydroxylation</term>
<term>Hypertension</term>
<term>Hypertensive</term>
<term>Ifosfamide</term>
<term>Imaoka</term>
<term>Immune</term>
<term>Immune response</term>
<term>Immunol</term>
<term>Inducer</term>
<term>Inducibility</term>
<term>Inducible</term>
<term>Inhibitor</term>
<term>Interethnic</term>
<term>Interferon</term>
<term>Interindividual</term>
<term>Iodothyronine</term>
<term>Isoform</term>
<term>Isoforms</term>
<term>Jacobson</term>
<term>Jiang</term>
<term>Johansson</term>
<term>Kadlubar</term>
<term>Kagawa</term>
<term>Karara</term>
<term>Kawajiri</term>
<term>Keeney</term>
<term>Kenna</term>
<term>Kimura</term>
<term>Krohn</term>
<term>Kunze</term>
<term>Kupfer</term>
<term>Kusunose</term>
<term>Laethem</term>
<term>Lancet</term>
<term>Lauric</term>
<term>Leeder</term>
<term>Lett</term>
<term>Leukocyte</term>
<term>Leydig</term>
<term>Liddle</term>
<term>Lipid</term>
<term>Liver</term>
<term>Liver disease</term>
<term>Liver microsomes</term>
<term>Loeper</term>
<term>Lung cancer</term>
<term>Lymphocyte</term>
<term>Macrolide</term>
<term>Makita</term>
<term>Male rats</term>
<term>Mansuy</term>
<term>Masimirembwa</term>
<term>Mcgi</term>
<term>Mclean</term>
<term>Mediator</term>
<term>Mephenytoin</term>
<term>Metab</term>
<term>Metabolic</term>
<term>Metabolic ratios</term>
<term>Metaboliser</term>
<term>Metabolisers</term>
<term>Metabolism</term>
<term>Metabolite</term>
<term>Metabolizers</term>
<term>Metabolizing</term>
<term>Microsomal</term>
<term>Microsome</term>
<term>Mimicry</term>
<term>Mitochondrial</term>
<term>Mitochondrion</term>
<term>Molecular aspects</term>
<term>Molecular mimicry</term>
<term>Molecular oxygen</term>
<term>Monooxygenase</term>
<term>Montellano</term>
<term>Morais</term>
<term>Mrna</term>
<term>Mrna levels</term>
<term>Mspi</term>
<term>Mutant</term>
<term>Mutation</term>
<term>Nadph</term>
<term>Natl</term>
<term>Nebert</term>
<term>Neoantigen</term>
<term>Neufeld</term>
<term>Nonsteroidogenic</term>
<term>Oates</term>
<term>Okuda</term>
<term>Oliw</term>
<term>Omeprazole</term>
<term>Omura</term>
<term>Oriental populations</term>
<term>Orphenadrine</term>
<term>Ortiz</term>
<term>Other hand</term>
<term>Ovarian</term>
<term>Oxidase</term>
<term>Oxidative</term>
<term>Oxidative metabolism</term>
<term>Oxidized</term>
<term>Oxygenase</term>
<term>Pahs</term>
<term>Pathophysiological</term>
<term>Pathophysiology</term>
<term>Pathway</term>
<term>Peptide</term>
<term>Persson</term>
<term>Pessayre</term>
<term>Pharm</term>
<term>Pharmacogenetics</term>
<term>Pharmacokinetic</term>
<term>Pharmacol</term>
<term>Phenobarbital</term>
<term>Phenotype</term>
<term>Phenotypic</term>
<term>Phenotyping</term>
<term>Phenytoin</term>
<term>Physiol</term>
<term>Plasma membrane</term>
<term>Platelet</term>
<term>Polycyclic</term>
<term>Polyglandular</term>
<term>Polymorphic</term>
<term>Polymorphism</term>
<term>Polymorphonuclear</term>
<term>Poor metabolisers</term>
<term>Pregnenolone</term>
<term>Prev</term>
<term>Proc</term>
<term>Procarcinogens</term>
<term>Progesterone</term>
<term>Proguanil</term>
<term>Propranolol</term>
<term>Prostaglandin</term>
<term>Prostanoids</term>
<term>Prosthetic</term>
<term>Protein levels</term>
<term>Rahman</term>
<term>Reactive</term>
<term>Reactive metabolite</term>
<term>Reactive metabolites</term>
<term>Receptor</term>
<term>Recognise</term>
<term>Recombinant</term>
<term>Reductase</term>
<term>Renal</term>
<term>Reticulum</term>
<term>Rifampicin</term>
<term>Riley</term>
<term>Schuetz</term>
<term>Schwartzman</term>
<term>Severe liver disease</term>
<term>Sharma</term>
<term>Shimada</term>
<term>Shunting</term>
<term>Sparteine</term>
<term>Steroid</term>
<term>Steroid hormones</term>
<term>Steroidogenesis</term>
<term>Steroidogenic</term>
<term>Sterol</term>
<term>Subfamily</term>
<term>Sugimura</term>
<term>Susceptibility</term>
<term>Synthase</term>
<term>Tamoxifen</term>
<term>Tanzanian</term>
<term>Tapner</term>
<term>Testis</term>
<term>Testosterone</term>
<term>Theophylline</term>
<term>Therapeut</term>
<term>Thromboxane</term>
<term>Thummel</term>
<term>Tienilic</term>
<term>Tienilic acid</term>
<term>Tinel</term>
<term>Tolbutamide</term>
<term>Toxicity</term>
<term>Toxicol</term>
<term>Transcriptional</term>
<term>Transferase</term>
<term>Ultrarapid</term>
<term>Ultrarapid metabolisers</term>
<term>Variant</term>
<term>Vergani</term>
<term>Wang</term>
<term>Watanabe</term>
<term>Waterman</term>
<term>Watkins</term>
<term>Waxman</term>
<term>Wrighton</term>
<term>Xenobiotic</term>
<term>Xenobiotica</term>
<term>Xenobiotics</term>
<term>Yamamoto</term>
<term>Yokotani</term>
<term>Zaluzny</term>
<term>Zeldin</term>
<term>Zhang</term>
<term>Zimbabwean</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr">
<term>Acide</term>
<term>Biochimie</term>
<term>Enzyme</term>
<term>Médiateur</term>
</keywords>
</textClass>
<langUsage>
<language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front>
<div type="abstract" xml:lang="en">Abstract: The cytochrome P450 proteins (CYPs) are a family of haem proteins resulting from expression of a gene super-family that currently contains around 1000 members in species ranging from bacteria through to plants and animals. In humans, about 40 different CYPs are present and these play critical roles by catalyzing reactions in: (a) the metabolism of drugs, environmental pollutants and other xenobiotics; (b) the biosynthesis of steroid hormones; (c) the oxidation of unsaturated fatty acids to intracellular messengers; and (d) the stereo- and regio-specific metabolism of fat-soluble vitamins. This review deals with aspects of cytochrome P450s of relevance to human physiology, biochemistry, pharmacology and medicine. Topics reviewed include: pharmacogenetics of CYPs, induction and inhibition of these haem proteins, their role in metabolism of endogenous compounds such as steroids and eicosanoids, the effect of disease on CYP function, CYPs and cancer, and CYPs as targets of antibodies in immune-mediated diseases.</div>
</front>
</TEI>
<affiliations>
<list>
<country>
<li>Australie</li>
<li>France</li>
<li>Zimbabwe</li>
<li>États-Unis</li>
</country>
<region>
<li>Tennessee</li>
<li>Texas</li>
<li>État de New York</li>
</region>
</list>
<tree>
<country name="Zimbabwe">
<noRegion>
<name sortKey="Hasler, Julia A" sort="Hasler, Julia A" uniqKey="Hasler J" first="Julia A" last="Hasler">Julia A. Hasler</name>
</noRegion>
<name sortKey="Hasler, Julia A" sort="Hasler, Julia A" uniqKey="Hasler J" first="Julia A" last="Hasler">Julia A. Hasler</name>
</country>
<country name="États-Unis">
<region name="Texas">
<name sortKey="Estabrook, Ronald" sort="Estabrook, Ronald" uniqKey="Estabrook R" first="Ronald" last="Estabrook">Ronald Estabrook</name>
</region>
<name sortKey="Capdevila, Jorge" sort="Capdevila, Jorge" uniqKey="Capdevila J" first="Jorge" last="Capdevila">Jorge Capdevila</name>
<name sortKey="Falck, John R" sort="Falck, John R" uniqKey="Falck J" first="John R" last="Falck">John R. Falck</name>
<name sortKey="Helvig, Christian" sort="Helvig, Christian" uniqKey="Helvig C" first="Christian" last="Helvig">Christian Helvig</name>
<name sortKey="Holla, Vijakumar" sort="Holla, Vijakumar" uniqKey="Holla V" first="Vijakumar" last="Holla">Vijakumar Holla</name>
<name sortKey="Kaminsky, Laurence S" sort="Kaminsky, Laurence S" uniqKey="Kaminsky L" first="Laurence S" last="Kaminsky">Laurence S. Kaminsky</name>
<name sortKey="Pikuleva, Irina" sort="Pikuleva, Irina" uniqKey="Pikuleva I" first="Irina" last="Pikuleva">Irina Pikuleva</name>
<name sortKey="Spivack, Simon D" sort="Spivack, Simon D" uniqKey="Spivack S" first="Simon D" last="Spivack">Simon D. Spivack</name>
<name sortKey="Waterman, Michael" sort="Waterman, Michael" uniqKey="Waterman M" first="Michael" last="Waterman">Michael Waterman</name>
</country>
<country name="Australie">
<noRegion>
<name sortKey="Murray, Michael" sort="Murray, Michael" uniqKey="Murray M" first="Michael" last="Murray">Michael Murray</name>
</noRegion>
<name sortKey="Farrell, Geoffrey" sort="Farrell, Geoffrey" uniqKey="Farrell G" first="Geoffrey" last="Farrell">Geoffrey Farrell</name>
</country>
<country name="France">
<noRegion>
<name sortKey="Boitier, Eric" sort="Boitier, Eric" uniqKey="Boitier E" first="Eric" last="Boitier">Eric Boitier</name>
</noRegion>
<name sortKey="Beaune, Philippe" sort="Beaune, Philippe" uniqKey="Beaune P" first="Philippe" last="Beaune">Philippe Beaune</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 00C441 | SxmlIndent | more

Ou

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 00C441 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Asie
   |area=    AustralieFrV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     ISTEX:AD6BE9C9C95C8D971CB1DA6AF0A78F5EB217FFA9
   |texte=   Human cytochromes P450
}}

Wicri

This area was generated with Dilib version V0.6.33.
Data generation: Tue Dec 5 10:43:12 2017. Site generation: Tue Mar 5 14:07:20 2024